Prince Frederik of Luxembourg, the son of Prince Robert and Princess Julie of Nassau, has passed away at the age of 22 following a long battle with POLG mitochondrial disease, a rare genetic disorder. His family confirmed the tragic news through statements on social media and the POLG Foundation website.
The prince, who had been residing in Paris, faced the challenges of POLG mitochondrial disease, a condition that gradually impairs the body’s cells, leading to organ failure. The POLG Foundation, a nonprofit organization focused on research and treatment for mitochondrial disorders, has been actively working toward finding a cure.
A Family’s Final Goodbye
In an emotional statement shared by Prince Robert, he described the poignant moments leading up to Frederik’s passing. “On ‘Rare Disease Day,’ February 28, Frederik summoned the strength to say goodbye to each member of our family — his brother Alexander, his sister Charlotte, myself, his cousins Charly, Louis, and Donall, his brother-in-law Mansour, as well as his Aunt Charlotte and Uncle Mark,” Prince Robert shared. “He even shared a final family joke, leaving us with one last laugh, a gesture that reflected his humor and compassion.”
Frederik’s mother, who had been by his side throughout his battle, was also with him during his final moments.
Understanding POLG Mitochondrial Disease
Prince Robert also provided insight into the rare disease that affected his son, revealing that although Frederik was born with POLG mitochondrial disease, it was not diagnosed until he was 14 years old. The disease gradually progressed, with symptoms becoming more apparent as Frederik grew older.
POLG mitochondrial disease is a complex genetic condition that leads to the depletion of cellular energy, affecting multiple organ systems, including the brain, liver, muscles, nerves, and digestive system. The condition is notoriously difficult to diagnose due to its wide range of symptoms, and unfortunately, no cure or effective treatment currently exists.
Frederik’s passing has not only left a profound impact on his family but also highlighted the urgent need for continued research into rare diseases like POLG mitochondrial disorder. The POLG Foundation remains dedicated to advancing research in hopes of finding a cure for this debilitating condition.
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