Exercise plays a critical role in managing metabolic dysfunction-associated steatotic liver disease (MASLD), a chronic liver condition previously known as non-alcoholic fatty liver disease (NAFLD), according to a recent study led by Indian-origin researcher Hirsh D. Trivedi. The research highlights the potential benefits of physical activity, even for patients with advanced liver disease, such as cirrhosis.
The study, conducted by Trivedi and his team at Cedars-Sinai Medical Center in California, United States, underscores the importance of exercise in reducing liver fat, improving biomarkers of inflammation, aiding weight loss, and promoting overall cardiovascular health. The findings were published in the Liver International journal.
MASLD occurs when excess fat builds up in the liver, often affecting individuals with underlying conditions such as diabetes, obesity, high blood pressure, or high cholesterol. For patients with cirrhosis, a condition marked by severe liver scarring, exercise can still provide significant therapeutic benefits. The study advocates for personalized exercise regimens for all MASLD patients, particularly those undergoing pharmacotherapy.
“Exercise is a valuable therapeutic tool throughout all stages of liver disease, including advanced stages like cirrhosis,” said Jonathan G. Stine, a member of the research team from Cedars-Sinai’s Department of Medicine. “Physical activity should not be restricted based solely on liver disease stage; even individuals living with cirrhosis can engage in safe and effective exercise.”
The study, which analyzed both pre-clinical and clinical data, revealed that increased physical activity is linked to reduced liver disease incidence and improved patient outcomes. The researchers emphasized the need for a systematic, evidence-based approach to prescribing exercise for MASLD patients, given its well-documented benefits. Regular exercise is shown to enhance insulin sensitivity, decrease hepatic fat accumulation, and lower inflammation markers associated with liver damage.
The research team calls for further investigation into exercise protocols, suggesting that refining exercise regimens could enhance their therapeutic impact for MASLD patients.
This study reinforces the growing body of evidence supporting exercise as an essential intervention in the management of steatotic liver disease, further underscoring its significance in improving liver health.
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