A recent systematic review and meta-analysis has revealed a significant association between endometriosis and an increased risk of cardiovascular disease (CVD). The study, which included an extensive review of literature, suggests that women with endometriosis face a heightened likelihood of developing both CVD and hypertension compared to those without the condition.
Background
Endometriosis is a chronic condition that affects millions of women worldwide, characterized by the growth of tissue similar to the lining of the uterus outside of it. Previous studies have suggested potential cardiovascular risks associated with this condition, but evidence remained inconclusive. This meta-analysis aimed to provide a more definitive evaluation of the relationship between endometriosis and cardiovascular outcomes, including hypertension.
Methods
Researchers conducted a comprehensive search of literature in prominent medical databases, including PubMed (Medline), Scopus, Web of Science, and Embase, spanning from January 2000 to April 2023. The inclusion criteria focused on cohort and case-control studies that investigated the relationship between endometriosis and cardiovascular disease. The study incorporated random-effects or fixed-effects models based on the heterogeneity of the studies analyzed. The primary statistical measure was the pooled relative risk (RR) with 95% confidence intervals (CIs), and the quality of each study was assessed using appropriate tools. The analysis adhered to the PRISMA 2020 guidelines for systematic reviews.
Results
A total of six studies were included in the final meta-analysis. The results showed that women with endometriosis had a 23% higher risk of developing cardiovascular disease compared to those without the condition (RR = 1.23; 95% CI: 1.16–1.31). Additionally, the risk of developing hypertension was found to be 13% higher among women with endometriosis (RR = 1.13; 95% CI: 1.10–1.16). Moderate statistical heterogeneity was observed across the included studies, which led the authors to apply a random-effects model for the analysis.
Conclusion
The findings of this meta-analysis underscore the elevated cardiovascular risks, particularly hypertension, faced by women with endometriosis. The study advocates for enhanced cardiovascular monitoring and preventive strategies for women suffering from this condition. These results provide further evidence of the broader health implications of endometriosis, emphasizing the need for a multidisciplinary approach to managing the long-term health of these patients.
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